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Giulio is a widower, struggling to raise three sons, Marco, Rudi, and Mimmo, as best he can. He lives in Rome's working-class Garbatella neighborhood and runs a wine shop with his two brothers. Lucia, meanwhile, comes from Milan's middle-class background; she's divorced and trying to rebuild her life with her two daughters, Eva and Alice. The two meet by chance and recognize each other: they had a fling as teenagers, many years earlier. Yet first love is never forgotten, and so Giulio and Lucia find themselves together again. Their meeting, however, changes not only the lives of a man and a woman, but also those of two families as different as could be. Two families who find themselves living under the same roof without even having had the time to get to know each other well.

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Blanca Ferrando is a young woman who became blind at the age of twelve, due to a dramatic fire in which her older sister Beatrice died and which was caused by her violent boyfriend, Sebastian. This tragedy made her develop a very strong sense of justice to the point of pushing her to join the police. Blanca is helped by her most trusted friends: her guide dog Linneo, a female bulldog who protects and comforts her in the most difficult moments, and her beautician friend, Stella. After overcoming her work challenges, she finds herself facing sentimental ones: torn between two men, Inspector Michele Liguori, a man of many secrets, and Nanni, a young cook.

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Police officer Elena deals with cyber crimes and violence against children. The discovery of a young boy's body in the Venetian Lagoon brings her back to the city she left twenty years earlier.

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Inspired by true events that occurred during the fierce rivalry between Germany (Audi) and Italy (Lancia) at the 1983 Rally World Championships.

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On July 19–21, 2001, over 200,000 people took to the streets of Genoa to protest against the ongoing G8 summit. Anti-globalization activists clashed with the police, with 23-year-old protester Carlo Giuliani shot dead after confronting a police vehicle. In the aftermath, the police organized a night raid on the Diaz high school, where around a hundred people between unarmed protesters—mostly students—and independent reporters who documented the police brutality during the protests had took shelter. What happened next was called by Amnesty International "the most serious breach of civil liberties in a democratic Western country since World War II."

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Samuel, a boy who lives with his mother Elena in Villa dei Laghi, an isolated manor surrounded by woods, feels trapped in the family routine, growing up seemingly protected, but unsatisfied and restless.

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On December 12, 1969, a bomb kills 17 people at the Piazza Fontana national bank in Milan, Italy, marking the beginning of the Years of Lead. Local anarchists are scapegoated for the massacre by police and the media, but a lone prosecutor uncovers a conspiracy of far-right groups, corrupt secret services, and other interests that seek to undermine democracy.

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For John Cuttin it all started with the first sip of the wine of her life. A "Marzemino", a typical wine of the province of Trento, quoted by Lorenzo Da Ponte in his libretto for "Don Giovanni" by Mozart. The instant he tasted the blood-red drop of nectar John felt a sort of pleasant and mysterious explosion of the senses, and from that moment on, his nature is transformed. In just three years, from shy bank clerk and faithful husband became director, tombeur de femmes and the most revered and respected expert on wine in Italy. Just as he had predicted the enigmatic "Professor" who had convinced him to taste his first glass of wine. The only event that the "Professor" with his accent and his piercing blue eyes, had not predicted was that he would soon be charged with the murder of his wife Adele. While being put under pressure by the Commissioner Sanfelice, John is to reflect on the last three years of his life, dominated by a single and mad passion: wine.

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In a scorching Rome, flooded with waste and electric scooters, Al is a serial dreamer who feels destined for success. When he helplessly witnesses the disintegration of his dream to make it big with his rock band, fate points him toward a second path: a phone containing evidence of a crime. With a knowledge of noir stories at his disposal, Al becomes convinced that he can solve the case. As he begins the investigation, he encounters Betty, a young adventure-seeking outsider, through a dating app. Both searching for a place in the world, they delve into a mystery that soon proves to be beyond their grasp.

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In an unspecified future the human race is struck by a light that pushes those who see it to suicide. But there is someone who tries to save those affected by facing the danger of becoming attached to them.